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Updated: Apr 3, 2026

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A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
Published on: August 22, 2025
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An approach to analyze the breast tissues in infrared images using nonlinear adaptive level sets and Riesz transform
S Prabha1, S S Suganthi2, C M Sujatha1
1Department of Electronics and Communication Engineering, College of Engineering Guindy, Anna University, Chennai, India.
Summary
This study presents an automated breast thermography analysis framework, improving early breast cancer detection. The method enhances image quality and accurately segments breast tissues, aiding in diagnosing abnormalities.
Area of Science:
- Medical Imaging
- Biomedical Engineering
- Computational Pathology
Background:
- Breast thermography offers potential for early breast cancer detection by analyzing temperature variations.
- Infrared images present challenges like low contrast and noise, complicating accurate breast tissue delineation.
Purpose of the Study:
- To develop an automated segmentation technique for breast tissues in thermal images.
- To extract characteristic features for analyzing thermal variations in normal and abnormal breast tissues.
Main Methods:
- Utilized nonlinear adaptive level sets and Riesz transform for automated breast thermal image analysis.
- Applied wavelet denoising and contrast-limited adaptive histogram equalization for image enhancement.
- Integrated phase map into level set framework for boundary estimation and Riesz transform for feature extraction.
Main Results:
- Achieved a 38% improvement in signal-to-noise ratio and 6% increase in image sharpness.
- Demonstrated high segmentation accuracy (98%) and regional overlap (99%) with ground truth.
- Identified significant differences (11%) in directionality between normal and abnormal breast tissues.
Conclusions:
- The proposed framework, with preprocessing, effectively aids in the early diagnosis of breast abnormalities using thermal imaging.
- The automated analysis enhances diagnostic capabilities for breast cancer detection.

