Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imbalances in Cardiac Output

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...

Heart Failure Drugs: Diuretics

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...

Disorder of Water Balance

Disorder of Water Balance

Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...

Heart Failure VI: Adjunct Therapies

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Heart Failure III: Clinical Manifestations

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Creatinine muscle index in UK Biobank: comparison with MRI and associations with frailty and mortality.

Clinical kidney journal·2026

Same author

Long-term outcomes for patients at high risk of death after surgery in the UK: a retrospective cohort study.

The Lancet. Public health·2026

Same author

Macronutrient excess in critical illness: too much of a good thing?

Current opinion in critical care·2026

Same author

Does ability and willingness to use continuous RRT improve patient outcomes? A few answers, plenty of questions and opportunities for research.

Intensive care medicine·2025

Same author

Rinaldo Bellomo: relentless architect of modern intensive care.

Intensive care medicine·2025

Same author

Uncertainty and decision-making in critical care: lessons from managing COVID-19 ARDS in preparation for the next pandemic.

BMJ open respiratory research·2025

Same journal

Critical Care and Contagion: Evolving Frontiers of Infectious Diseases in the Modern Intensive Care Unit.

Critical care clinics·2026

Same journal

Advances and Challenges in Sepsis Care in Low-Resource Settings.

Critical care clinics·2026

Same journal

The Respiratory Triple Pandemic in the Intensive Care Unit: Epidemiology, Clinical Features and Management of COVID-19, Influenza and Respiratory Syncytial Virus.

Critical care clinics·2026

Same journal

Antibiotic Stewardship for the Intensivist.

Critical care clinics·2026

Same journal

Infection Prevention and Control in the Intensive Care Unit.

Critical care clinics·2026

Same journal

Antibiotic Considerations in the Critically Ill: Empiric Choices and Dosing.

Critical care clinics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 3, 2026

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

Published on: August 17, 2022

Fluid Overload.

Michael E O'Connor¹, John R Prowle²

¹Adult Critical Care Unit, The Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, London E1 1BB, UK; Centre for Translational Medicine & Therapeutics, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

Critical Care Clinics

|September 28, 2015

Summary

This summary is machine-generated.

Critically ill patients often develop fluid overload due to fluid shifts and therapy. This review examines the harms of fluid overload and strategies for prevention and management in intensive care units.

Keywords:

Critical illness Diuretics Edema Fluid overload Ultrafiltration

More Related Videos

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Published on: January 12, 2024

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Published on: July 28, 2018

Related Experiment Videos

Last Updated: Apr 3, 2026

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

Published on: August 17, 2022

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Published on: January 12, 2024

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Published on: July 28, 2018

Area of Science:

Critical Care Medicine
Nephrology
Physiology

Background:

Critically ill patients frequently experience fluid shifts and hemodynamic instability.
Intravenous fluid administration is common but often leads to transient responses and subsequent fluid overload.
Fluid overload is a prevalent issue in intensive care units (ICUs).

Purpose of the Study:

To review the evidence linking fluid overload to patient harm.
To explore the physiological mechanisms driving fluid accumulation in critical illness.
To discuss strategies for preventing and managing fluid overload.

Main Methods:

Literature review of studies on fluid therapy, fluid overload, and critical illness.
Analysis of physiological processes contributing to fluid retention.
Examination of clinical evidence regarding the consequences of fluid overload.

Main Results:

Fluid overload is associated with significant patient harm in ICUs.
Physiological derangements in critical illness promote fluid accumulation.
Effective strategies for fluid management are crucial for improving outcomes.

Conclusions:

Understanding the pathophysiology of fluid overload is essential for clinical practice.
Proactive fluid management and timely interventions can mitigate the risks associated with fluid overload.
Further research into optimized fluid strategies is warranted.