Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Morphogenesis02:19

Morphogenesis

30.8K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.8K
The Phase Rule01:20

The Phase Rule

110
The phase rule describes the relationship between the variance (degrees of freedom), the number of components, and the number of phases in a system at equilibrium.Variance is a concept that denotes the number of independent intensive properties (properties are those that do not depend on the amount of material in the system), such as temperature, pressure, and composition, that can be altered without impacting the number of phases in equilibrium.In a single-component system, such as pure water,...
110
Determination01:51

Determination

21.4K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
21.4K
Psychosexual Theory of Development01:14

Psychosexual Theory of Development

3.4K
Sigmund Freud's psychosexual theory of development suggests that early childhood experiences significantly shape personality and behavior. Freud proposed that development is discontinuous, occurring in five distinct stages, each defined by a focus on different erogenous zones. He believed that failure to resolve the conflicts specific to each stage successfully could result in fixation, potentially influencing behavior as adults.
The Five Stages of Psychosexual Development
Freud's psychosexual...
3.4K
Piaget's Stage 1 of Cognitive Development01:14

Piaget's Stage 1 of Cognitive Development

2.4K
The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
Exploration...
2.4K
Cleavage and Blastulation01:33

Cleavage and Blastulation

51.4K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
51.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The elephant in the room: impact factor.

Development (Cambridge, England)·2026
Same author

Boundary constraints can determine pattern emergence.

Development (Cambridge, England)·2026
Same author

The notochord: development, disease and stem cell-based modelling.

Development (Cambridge, England)·2026
Same author

Development's 2025 Outstanding Paper Prize.

Development (Cambridge, England)·2026
Same author

'Why is publishing so expensive?'

Development (Cambridge, England)·2026
Same author

Gene regulatory networks: from correlative models to causal explanations.

Nature reviews. Genetics·2026
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

10.1K

Developmental Pattern Formation in Phases.

Anna Kicheva1, James Briscoe1

  • 1The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, NW71AA, UK.

Trends in Cell Biology
|September 28, 2015
PubMed
Summary
This summary is machine-generated.

Developing organs refine cell types and gene expression through distinct phases. Understanding transitions in morphogen signaling and tissue growth is key to reproducible developmental patterns.

Keywords:
morphogen patterningneural tubetissue growthtissue size scaling

More Related Videos

Cell Co-culture Patterning Using Aqueous Two-phase Systems
10:11

Cell Co-culture Patterning Using Aqueous Two-phase Systems

Published on: March 26, 2013

19.6K
Understanding Cerebellar Pattern Formation
13:18

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

5.6K

Related Experiment Videos

Last Updated: Apr 3, 2026

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

10.1K
Cell Co-culture Patterning Using Aqueous Two-phase Systems
10:11

Cell Co-culture Patterning Using Aqueous Two-phase Systems

Published on: March 26, 2013

19.6K
Understanding Cerebellar Pattern Formation
13:18

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

5.6K

Area of Science:

  • Developmental biology
  • Cellular and molecular biology

Background:

  • Cellular transcriptional states evolve during organ development.
  • Tissue growth and gene expression patterns are intricately linked.
  • Morphogen signaling and transcriptional networks guide cell fate decisions.

Purpose of the Study:

  • To discuss the dynamic transitions between distinct phases of pattern formation during development.
  • To explore the mechanisms controlling reproducible pattern establishment in developing tissues.

Main Methods:

  • Review of recent studies on developmental pattern formation dynamics.
  • Analysis of the interplay between cell identity, tissue growth, and gene expression.
  • Discussion of signaling pathways and transcriptional network control.

Main Results:

  • Pattern formation involves sequential phases: cell type specification followed by growth-driven elaboration.
  • Transitions between these phases are regulated by morphogen signaling and transcriptional networks.
  • Understanding these transitions is crucial for explaining the reproducibility of developmental patterns.

Conclusions:

  • The study highlights the importance of distinct phases and their transitions in establishing reproducible developmental patterns.
  • Mechanisms governing these transitions offer insights into developmental robustness and potential disruptions.