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Galectin-3 binding protein in human preterm infant umbilical cord plasma
Journal of Neonatal-Perinatal Medicine
|September 28, 2015
Summary
Galectin-3 binding protein (Gal3BP) is elevated in preterm infants' cord plasma. This finding suggests prematurity may be linked to inflammatory conditions in newborns and mothers.
Area of Science:
- Neonatal Immunology
- Biochemistry
Background:
- Galectin-3 binding protein (Gal3BP) is a glycoprotein found in colostrum.
- Gal3BP may possess immunologically active properties influencing the neonatal immune system.
- Previous studies detected Gal3BP in term infants, but not in preterm infants.
Purpose of the Study:
- To compare umbilical cord plasma Gal3BP concentrations between preterm and term infants.
- To investigate the association between maternal and infant clinical factors and Gal3BP levels.
Main Methods:
- An observational study involving mother-infant pairs.
- Umbilical cord plasma samples collected at birth.
- Gal3BP concentration measured using ELISA.
Main Results:
- Gal3BP levels were significantly higher in preterm infants compared to term infants.
- Elevated Gal3BP was associated with prematurity, maternal diabetes, antenatal steroid exposure, and parity.
- Chorioamnionitis showed a decrease in Gal3BP levels.
Conclusions:
- Umbilical cord plasma Gal3BP concentration is elevated in preterm infants.
- This elevation may indicate inflammatory states in both mother and infant.
- Further research is needed to elucidate the implications of these findings.
