Paget Disease of Bone.
Mamun Al-Rashid1, Dipak B Ramkumar2, Kevin Raskin3
1Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
The Orthopedic Clinics of North America
|September 28, 2015
Summary
Paget disease of bone (PDB) management has evolved, with surgery reserved for specific complications. While treatments improve function, a small percentage of patients may still develop Paget sarcoma.
Area of Science:
- Orthopedics
- Bone Metabolism
- Skeletal Pathologies
Background:
- Paget disease of bone (PDB) understanding has significantly advanced since its initial description in 1877.
- Medical management is the primary treatment approach for PDB.
- Surgical interventions for PDB are typically reserved for specific complications and advanced cases.
Purpose of the Study:
- To provide an overview of the current understanding and management of Paget disease of bone.
- To highlight the role of surgical interventions in managing PDB complications.
- To acknowledge the risk of Paget sarcoma in a subset of PDB patients.
Main Methods:
- Review of historical and current medical literature on Paget disease of bone.
- Analysis of indications for surgical intervention in PDB.
- Discussion of advancements in surgical techniques and outcomes.
Main Results:
- Medical management remains the cornerstone of PDB treatment.
- Surgical interventions are indicated for fractures, deformities, impending fractures, severe arthritis, and neural compression.
- Surgical advancements facilitate earlier patient mobilization and functional recovery.
Conclusions:
- Paget disease of bone management has evolved, integrating medical and surgical approaches.
- While effective, current treatments do not eliminate the risk of developing Paget sarcoma in a small patient subset.
- Continued research and advancements are crucial for improving PDB patient outcomes.
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