Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Cancer Therapies02:49

Cancer Therapies

10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.5K
1.5K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Red Cell Transfusion in Critically Ill and Noncritically Ill Patients With Acute Myocardial Infarction and Anemia-A Subanalysis of the Myocardial Ischemia and Transfusion (MINT) Trial.

Critical care medicine·2026
Same author

Predictors of ischemic stroke and major bleeding among patients with atrial fibrillation in clinical practice.

American heart journal·2026
Same author

The Society of Thoracic Surgeons 2026 Clinical Practice Guidelines for the Prevention and Treatment of New-Onset Postoperative Atrial Fibrillation After Cardiac Surgery.

The Annals of thoracic surgery·2026
Same author

Stereotactic Body Radiation Therapy for Non-Spine Bone Metastases: A Case-Based Radiosurgery Society Review.

Practical radiation oncology·2026
Same author

A comprehensive set of per-protocol analyses of the myocardial ischemia and transfusion (MINT) trial.

American heart journal·2026
Same author

Evaluation of the updated ABC-AF-bleeding score 2.0 in patients with atrial fibrillation treated with a direct oral anticoagulant or warfarin.

Journal of thrombosis and haemostasis : JTH·2026

Related Experiment Video

Updated: Apr 2, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.4K

Targeted Chemotherapy in Bone and Soft-Tissue Sarcoma.

Jared L Harwood1, John H Alexander1, Joel L Mayerson1

  • 1Department of Orthopaedics, The Ohio State University, 725 Prior Hall, 376 West 10 Avenue, Columbus, OH 43210, USA.

The Orthopedic Clinics of North America
|September 28, 2015
PubMed
Summary

Targeted chemotherapy offers improved outcomes and fewer side effects for bone and soft-tissue sarcomas, advancing beyond traditional treatments. This approach focuses on specific molecular targets for more personalized and effective sarcoma treatment.

Keywords:
BoneChemotherapySarcomaTargetedTumor

More Related Videos

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

15.3K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.8K

Related Experiment Videos

Last Updated: Apr 2, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.4K
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

15.3K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.8K

Area of Science:

  • Oncology
  • Molecular Biology
  • Surgical Oncology

Background:

  • Traditional treatments for bone and soft-tissue sarcomas, including surgery and radiation, have limitations.
  • Cytotoxic chemotherapy, while revolutionary, presents significant side effects and has seen plateaued outcomes.
  • The advent of targeted therapies marks a paradigm shift in sarcoma treatment.

Purpose of the Study:

  • To review the historical evolution of sarcoma treatment modalities.
  • To explore the fundamental science of sarcomatogenesis (tumor formation).
  • To identify and discuss key molecular targets and pathways for novel therapies.

Main Methods:

  • Literature review of historical and contemporary sarcoma treatment strategies.
  • Analysis of basic science research on sarcoma development.
  • Examination of current research on targeted therapies and their mechanisms.

Main Results:

  • Significant increase in research on targeted chemotherapy since imatinib's approval in 2002.
  • Identification of numerous molecular targets and pathways implicated in sarcoma.
  • Demonstration of potential for reduced toxicity and enhanced efficacy with targeted agents.

Conclusions:

  • Targeted therapies represent a promising advancement in sarcoma treatment.
  • Personalized treatment strategies based on molecular targets offer potential for improved patient outcomes.
  • Continued research into sarcomatogenesis and targeted pathways is crucial for future therapeutic development.