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Published on: May 4, 2018
SENSITIVITY PATTERNS OF PSEUDOMONAS AERUGINOSA ISOLATES OBTAINED FROM CLINICAL SPECIMENS IN PESHAWAR
Background:
Pseudomonas aeruginosa (P. aeruginosa) is a highly virulent opportunistic pathogen and a leading cause of nosocomial infections. Affected patients are often hospitalized in an intensive care unit, and are immuno-compromised as a result of disease and treatment. Suspected P. aeruginosa require timely, adequate and empirical antibiotic therapy to ensure improved outcomes. The purpose of the study was to find the sensitivity and resistance pattern of P. aeruginosa to various groups of drugs, in clinical isolates collected from two major tertiary care hospitals of Peshawar.
Methods:
Different clinical isolate were taken from patients admitted in various wards of Khyber Teaching Hospital and Lady Reading Hospital Peshawar.
Results:
A total of 258 clinical isolates were positive for P. aeruginosa out of 2058 clinical isolates. Pseudomonas showed high degree of resistance to third generation Cephalosporins (Ceftazidime, and Ceftriaxone) and moderate degree of resistance to Quinolones and Aminoglycosides (Ofloxacin, Ciprofloxacin, Levofloxacin and Amikacin). Low resistance was observed to different combinations (Cefoperazone+Sulbactum, Piperacillin+Tazobactum). Meropenem and Imipenem had negligible resistance.
Conclusion:
There is growing resistance to different classes of antibiotics. Combination drugs are useful approach for empirical treatment in suspected Pseudomonas infection. Imipenem and Meropenem are extremely effective but should be in reserve.
Insights
Pseudomonas aeruginosa exhibits high resistance to common antibiotics like cephalosporins. Combination drugs and reserve antibiotics such as meropenem and imipenem show greater effectiveness against this pathogen.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Pseudomonas aeruginosa is a significant opportunistic pathogen causing nosocomial infections, particularly in immunocompromised patients.
- Timely and effective antibiotic therapy is crucial for improving outcomes in suspected Pseudomonas aeruginosa infections.
Purpose of the Study:
- To determine the antibiotic sensitivity and resistance patterns of clinical isolates of Pseudomonas aeruginosa.
- To evaluate drug resistance in two major tertiary care hospitals in Peshawar.
Main Methods:
- Analysis of 2058 clinical isolates to identify Pseudomonas aeruginosa.
- Testing sensitivity and resistance of identified isolates against various antibiotic groups.
Main Results:
- 258 clinical isolates were positive for Pseudomonas aeruginosa.
- High resistance observed against third-generation cephalosporins (ceftazidime, ceftriaxone).
- Moderate resistance to quinolones and aminoglycosides; low resistance to combination drugs (cefoperazone+sulbactam, piperacillin+tazobactam).
- Negligible resistance to meropenem and imipenem.
Conclusions:
- Increasing antibiotic resistance in Pseudomonas aeruginosa necessitates careful treatment strategies.
- Combination antibiotics offer a viable approach for empirical treatment of suspected Pseudomonas infections.
- Meropenem and imipenem demonstrate high efficacy and should be preserved for resistant cases.
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