Related Experiment Video

Updated: Apr 2, 2026

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

17.0K

Adverse Drug Events in Children: How Big is the Problem?

Peter J Zed1

  • 1Faculty of Pharmaceutical Sciences, The University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3. peter.zed@ubc.ca.

Drug Metabolism Letters
|September 29, 2015
PubMed

Insights

Adverse drug events (ADEs) in children are a major cause of emergency visits and hospitalizations. Further research is needed to understand causes and improve prevention and management strategies for pediatric ADEs.

Area of Science:

  • Pediatric pharmacology
  • Patient safety
  • Healthcare quality

Background:

  • Adverse drug events (ADEs) in children are a significant cause of healthcare utilization, including emergency department visits and hospital admissions.
  • Despite increased understanding, critical questions remain regarding the etiology, prevention, and management of pediatric ADEs.
  • Understanding patient, drug, and system factors is crucial for addressing ADEs in children.

Purpose of the Study:

  • To review current knowledge on the frequency, severity, preventability, and classification of ADEs in children.
  • To identify challenges and unanswered questions concerning factors contributing to pediatric ADEs.
  • To outline future research directions for improving the understanding, recognition, and management of ADEs in children.

Main Methods:

  • Literature review and synthesis of existing data on pediatric adverse drug events.
  • Analysis of factors contributing to ADEs, including patient-specific, drug-specific, and system-related elements.
  • Identification of knowledge gaps and areas for future research in pediatric ADEs.

Main Results:

  • Pediatric ADEs represent a substantial burden on healthcare resources.
  • Significant knowledge gaps persist regarding the root causes and effective prevention strategies for ADEs in children.
  • Challenges in classifying and recognizing ADEs in pediatric populations require further investigation.

Conclusions:

  • Further research is essential to elucidate the etiology of ADEs in children.
  • Improved strategies for prevention, early recognition, and management of pediatric ADEs are needed.
  • Addressing pediatric ADEs is critical to minimize their impact on children, families, and the healthcare system.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.7K
Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

2.6K

Related Concept Videos

Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
182
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.9K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
375
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
783
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
732
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
81