Related Experiment Video

Updated: Apr 2, 2026

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

1.6K

[Impacts of high-volume hemofiltration on hemodynamics and vascular endothelial permeability in children with septic

Xun Si-Tu1, Jian-Hui Zhang, Jian-Ping Tao

  • 1Pediatric Intensive Care Unit, Guangzhou Women and Childrenγs Medical Center, Guangzhou 510623, China. 917589592@qq.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|September 29, 2015
PubMed

Insights

High-volume hemofiltration (HVHF) significantly improves hemodynamics and vasoactive factors in children with septic shock. HVHF also reduces vascular endothelial permeability compared to standard-volume hemofiltration (SVHF).

Area of Science:

  • Pediatric Critical Care Medicine
  • Renal Replacement Therapy
  • Pediatric Septic Shock Pathophysiology

Context:

  • Septic shock in children is a life-threatening condition characterized by hemodynamic instability and organ dysfunction.
  • Vascular endothelial dysfunction plays a crucial role in the pathogenesis of septic shock.
  • Hemofiltration is a supportive therapy used in critically ill children, but optimal modality remains under investigation.

Purpose:

  • To comparatively analyze the effects of high-volume hemofiltration (HVHF) versus standard-volume hemofiltration (SVHF) on pediatric septic shock.
  • To evaluate the impact of HVHF on hemodynamic parameters, vasoactive factors, and endothelial permeability in pediatric septic shock.

Summary:

  • A randomized controlled trial involving 36 children with septic shock compared HVHF to SVHF.
  • HVHF demonstrated significant improvements in mean arterial pressure, oxygen saturation, and heart rate compared to SVHF.
  • HVHF led to favorable modulation of vasoactive factors (TXB2, sE-selectin, 6-keto-PGF1α, EDRF) and reduced vascular endothelial permeability.

Impact:

  • HVHF emerges as a more effective therapeutic strategy for managing pediatric septic shock.
  • This approach may mitigate endothelial damage and improve circulatory function in critically ill children.
  • Findings support the use of HVHF for optimizing outcomes in pediatric septic shock patients.
Abstract

More Related Videos

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

25.8K
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

16.8K

Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.8K
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
3.3K
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.9K
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
333
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
350
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.9K