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Therapeutic application of mesenchymal stem cells in osteoarthritis
Maxime Ruiz1,2, Stella Cosenza1,2, Marie Maumus1,2
1a 1 Inserm, U1183, CHRU Saint Eloi, Hôpital Saint-Eloi , 80 avenue Augustin Fliche, Montpellier, F-34295, France +33 4 67 33 04 73 ; +33 4 67 33 01 13 ; daniele.noel@inserm.fr.
Introduction:
Osteoarthritis (OA) is a degenerative disease characterized by cartilage degradation and subchondral bone alterations. This disease represents a global public health problem whose prevalence is rapidly growing with the increasing aging of the population. With the discovery of mesenchymal stem cells (MSC) as possible therapeutic agents, their potential for repairing cartilage damage in OA is under investigation.
Areas Covered:
Characterization of MSCs and their functional properties are mentioned with an insight into their trophic function and secretory profile. We present a special focus on the types of extracellular vesicles (EVs) that are produced by MSCs and their role in the paracrine activity of MSCs. We then discuss the therapeutic approaches that have been evaluated in pre-clinical models of OA and the results coming out from the clinical trials in patients with OA.
Expert Opinion:
MSC-based therapy seems a promising approach for the treatment of patients with OA. Further research is still needed to demonstrate their efficacy in clinical trials using controlled, prospective studies. However, the emergence of MSC-derived EVs as possible therapeutic agents could be an alternative to cell-based therapy.
Insights
Mesenchymal stem cells (MSC) show promise for osteoarthritis treatment by repairing cartilage. MSC-derived extracellular vesicles (EVs) offer a potential alternative to cell-based therapies for this degenerative joint disease.
Area of Science:
- Orthopedics
- Regenerative Medicine
- Cell Biology
Background:
- Osteoarthritis (OA) is a prevalent degenerative joint disease causing cartilage degradation and bone changes.
- Increasing global prevalence due to aging populations highlights the urgent need for effective OA treatments.
- Mesenchymal stem cells (MSCs) are being investigated for their potential to repair cartilage damage in OA.
Purpose of the Study:
- To review the therapeutic potential of MSCs for osteoarthritis.
- To explore the role of MSC-derived extracellular vesicles (EVs) in OA treatment.
- To summarize preclinical and clinical findings of MSC-based therapies for OA.
Main Methods:
- Characterization of MSCs and their functional properties, including trophic function.
- Focus on MSC-derived extracellular vesicles (EVs) and their paracrine activity.
- Review of therapeutic approaches evaluated in preclinical OA models and clinical trials.
Main Results:
- MSC-based therapy demonstrates potential for treating osteoarthritis.
- MSC-derived EVs show promise as therapeutic agents.
- Preclinical and clinical data suggest efficacy, but further controlled studies are needed.
Conclusions:
- MSC-based therapy is a promising avenue for OA treatment.
- Further rigorous clinical trials are necessary to confirm efficacy.
- MSC-derived EVs present a viable alternative to cell-based OA therapies.
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