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[Automatic re-utilization of capillary dialysis].

T Szepietowski1, J Uzar

  • 1Katedra i Klinika Nefrologii Akademii Medycznej we Wrocławiu.

Polimery W Medycynie
|January 1, 1989
PubMed
Summary

Multiple uses of Cuprophan capillary dialyzers are safe and effective. This automated method ensures sterility, maintains creatinine clearance, and reduces costs without adverse patient effects, making hemodialysis more accessible.

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Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Materials Science

Background:

  • Cuprophan capillary dialyzers are essential for hemodialysis.
  • Dialyzer reuse is a practice aimed at cost reduction and resource management.
  • Ensuring the safety and efficacy of reused dialyzers is critical for patient outcomes.

Purpose of the Study:

  • To evaluate the feasibility and safety of multiple uses for Cuprophan capillary dialyzers.
  • To assess the impact of a novel automated regeneration method on dialyzer performance.
  • To compare patient outcomes and biochemical markers between single-use and multiple-use dialyzers.

Main Methods:

  • Utilized Organon Technika Andante H.F. Cuprophan capillary dialyzers (0.8 m² surface area).
  • Implemented an automated regeneration process ensuring complete sterility and disinfectant removal.
  • Monitored creatinine clearance, patient blood parameters (urea, creatinine, etc.), and adverse events over 1075 dialyses.

Main Results:

  • Creatinine clearance remained consistent, with no significant drop from first to sixth use (105.8 ± 8.9 ml/min vs. 105.5 ± 9.8 ml/min).
  • No remarkable changes were observed in patient blood urea, creatinine, hydrogen carbonates, fibrinogen, hematocrit, hemoglobin, hematocytes, platelets, or weight.
  • No negative phenomena attributable to dialyzer reuse were observed in patients during 1075 reutilized dialyses.

Conclusions:

  • The automated method for dialyzer reutilization does not compromise hemodialysis efficiency.
  • Multiple dialyzer use reduces the risk of the 'first use syndrome' and is well-tolerated by patients.
  • This approach offers significant cost savings for dialysis procedures.

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