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Updated: Apr 2, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
A vegetable oil-based organogel for use in pH-mediated drug delivery
Mthulisi Khuphe1, Blessing Mukonoweshuro2, Algy Kazlauciunas1
1School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK. p.d.thornton@leeds.ac.uk.
Abstract:
Organogels prepared with vegetable oils as the liquid organic phase present an excellent platform for the controlled delivery of hydrophobic guest molecules. We disclose a graft copolymer comprised of a poly(L-serine) backbone linked to alkane side-chains by hydrolytically susceptible ester bonds, that is capable of gelating edible safflower oil. The thermoresponsive organogel formed, which is non-cytotoxic, is capable of withholding guest molecules before undergoing targeted disassembly upon incubation in solutions of acidic pH, permitting the directed release of payload molecules. The presented material offers an extremely promising candidate for the controlled delivery of hydrophobic agents within acidic environments, such as cancer tumour sites.
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