A positive-negative mode of population covariation links brain connectivity, demographics and behavior
Stephen M Smith1, Thomas E Nichols2, Diego Vidaurre3
1Oxford University Centre for Functional MRI of the Brain (FMRIB), Oxford, UK.
Abstract:
We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.
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