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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis

Thomas J Wilkinson1, Andrew B Lemmey1, Jeremy G Jones2

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Summary
This summary is machine-generated.

Creatine supplementation in rheumatoid arthritis patients increased muscle mass but did not improve strength or physical function. This suggests creatine may be a safe adjunctive therapy for reducing muscle wasting in RA.

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Area of Science:

  • Rheumatology
  • Sports Medicine
  • Nutritional Science

Background:

  • Rheumatoid arthritis (RA) is associated with rheumatoid cachexia, leading to muscle wasting, reduced strength, and impaired physical function.
  • Muscle wasting in RA significantly impacts patients' quality of life and mobility.

Purpose of the Study:

  • To evaluate the efficacy of oral creatine (Cr) supplementation in enhancing lean mass, strength, and physical function in RA patients.
  • To determine if creatine supplementation can counteract muscle loss associated with rheumatoid cachexia.

Main Methods:

  • A 12-week double-blind, randomized controlled trial involving 40 RA patients.
  • Participants received either creatine or placebo supplementation.
  • Body composition (dual x-ray absorptiometry, BIS), strength, and physical function were assessed at multiple time points.

Main Results:

  • Creatine supplementation significantly increased appendicular lean mass (ALM) and total lean mass (LM).
  • Increases in lean mass correlated with gains in intracellular water measured by BIS.
  • No significant improvements were observed in isometric knee extensor strength, handgrip strength, or physical function compared to placebo.

Conclusions:

  • Oral creatine supplementation effectively increased muscle mass in RA patients.
  • Creatine did not enhance muscle strength or physical function in this cohort.
  • Creatine appears to be a safe and well-tolerated adjunct therapy for mitigating muscle loss in RA patients, particularly those with severe rheumatoid cachexia.