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Updated: Apr 2, 2026

Behavioral Approaches to Studying Innate Stress in Zebrafish
Published on: May 1, 2019
Effects of waterborne fluoxetine on stress response and osmoregulation in zebrafish
Murilo S Abreu1, Ana Cristina V Giacomini2, Gessi Koakoski1
1Universidade Federal de Santa Maria (UFSM), Programa de Pós-Graduação em Farmacologia, Campus Universitário, Camobi, Santa Maria, RS, Brazil.
Abstract:
The presence of fluoxetine in aquatic environments has been reported for decades. Here, we investigate the effects of exposure to fluoxetine on the stress response and osmoregulation in zebrafish. We show that stress response alters osmoregulation and that fluoxetine inhibits these stress-related changes in osmoregulation. The results suggest that the presence of fluoxetine in aquatic ecosystems can cause changes in response to stress and osmoregulation in fish.

