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Related Concept Videos

Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
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Chronic fatigue syndrome.

Anthony J Cleare1, Steven Reid, Trudie Chalder

  • 1King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Affective Disorders, Department of Psychological Medicine, London, UK.

BMJ Clinical Evidence
|September 29, 2015
PubMed
Summary
This summary is machine-generated.

This systematic overview evaluated treatments for chronic fatigue syndrome (CFS). It categorized the effectiveness of antidepressants, cognitive behavioral therapy, corticosteroids, and graded exercise therapy for CFS patients.

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Area of Science:

  • Medical Research
  • Systematic Overviews
  • Clinical Effectiveness

Background:

  • Chronic fatigue syndrome (CFS) impacts 0.006% to 3% of the population.
  • Women are disproportionately affected by CFS.
  • Prevalence varies based on diagnostic criteria.

Purpose of the Study:

  • To systematically review the effects of treatments for chronic fatigue syndrome.
  • To answer the clinical question regarding the efficacy of selected CFS interventions.

Main Methods:

  • Conducted a systematic overview of existing literature.
  • Searched major databases (Medline, Embase, Cochrane Library) up to November 2013.
  • Evaluated 15 full publications, including systematic reviews and RCTs, using GRADE methodology.

Main Results:

  • Identified and screened 169 studies, ultimately reviewing 15 full articles.
  • Included two systematic reviews and one RCT at this update.
  • Performed GRADE evaluation for 23 PICO combinations.

Conclusions:

  • Categorized the effectiveness of four key interventions for chronic fatigue syndrome.
  • Assessed the safety and effectiveness of antidepressants, cognitive behavioral therapy, corticosteroids, and graded exercise therapy.