MicroRNAs; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis
Fatemeh Pourrajab1,2, Abbas Vakili Zarch1, Seyedhossein Hekmatimoghaddam3
1School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract:
The age-related senescence of adult tissues is associated with the decreased level of angiogenic capability and with the development of a degenerative disease such as atherosclerosis which thereafter result in the deteriorating function of multiple systems. Findings indicate that tissue senescence not only diminishes repair processes but also promotes atherogenesis, serving as a double-edged sword in the development and prognosis of ischaemia-associated diseases. Evidence evokes microRNAs (miRNAs) as molecular switchers that underlie cellular events in different tissues. Here, miRNAs would promote new potential targets for optimizing therapeutic methods in blood flow recovery to the ischaemic area. Effectively beginning an ischaemia therapy, a more characteristic of miRNA changes in adult tissues is prerequisite and in the forefront. It may also be a preliminary phase in treatment strategies by stem cell-based therapy.
Insights
Tissue aging (senescence) reduces blood vessel formation and worsens atherosclerosis, impacting recovery from ischemia. MicroRNAs (miRNAs) are key regulators, offering potential therapeutic targets for improving blood flow and aiding stem cell therapies.
Area of Science:
- Molecular Biology
- Gerontology
- Cardiovascular Research
Background:
- Age-related tissue senescence is linked to reduced angiogenesis and increased atherosclerosis.
- Tissue senescence impairs repair processes and promotes atherogenesis, complicating ischemic diseases.
- MicroRNAs (miRNAs) are implicated as critical regulators of cellular events in senescence.
Purpose of the Study:
- To explore the role of microRNAs (miRNAs) in age-related tissue senescence and its impact on ischemic diseases.
- To identify miRNAs as potential therapeutic targets for enhancing blood flow recovery in ischemic areas.
- To establish the significance of understanding miRNA changes in adult tissues for effective ischemia therapy.
Main Methods:
- Review of evidence implicating microRNAs in cellular senescence and tissue repair.
- Analysis of the dual role of tissue senescence in diminishing repair and promoting atherogenesis.
- Exploration of miRNA profiles in adult tissues as a prerequisite for therapeutic strategies.
Main Results:
- Tissue senescence acts as a double-edged sword, hindering repair while promoting atherosclerosis.
- MicroRNAs are identified as key molecular switches governing cellular events in senescence.
- miRNAs present promising targets for optimizing therapeutic interventions for ischemia.
Conclusions:
- Understanding characteristic miRNA changes in adult tissues is crucial for developing effective ischemia therapies.
- MicroRNAs offer novel targets for improving blood flow recovery to ischemic regions.
- miRNA-based approaches may serve as a preliminary phase in stem cell-based therapies for ischemic conditions.
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