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Prevalence of Cardiovascular Disease and Cardiac Symptoms: Left and Right Ventricular Function in Adults With

Zoran Radunovic1, Kjetil Steine2

  • 1Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

The Canadian Journal of Cardiology
|September 30, 2015
PubMed

Insights

Osteogenesis imperfecta (OI) patients commonly experience cardiac symptoms and ECG abnormalities. This study found impaired heart function in OI patients, particularly affecting the right ventricle.

Area of Science:

  • Cardiology
  • Genetics
  • Bone Diseases

Background:

  • Osteogenesis imperfecta (OI), or brittle bone disease, is a genetic disorder affecting connective tissue, primarily due to type-I collagen deficiency.
  • This collagen deficiency impacts bone integrity and may affect other organs, including the heart.

Purpose of the Study:

  • To investigate the prevalence of cardiomyopathy, ECG abnormalities, and cardiovascular symptoms in adults with Osteogenesis imperfecta.
  • To compare cardiac function between OI patients and healthy controls.

Main Methods:

  • A study of 99 adults with Osteogenesis imperfecta (types I, III, IV) and 52 controls from Norway's national OI registry.
  • Evaluations included medical history, physical examination, ECG, and echocardiography to assess left ventricular (LV) and right ventricular (RV) function.

Main Results:

  • Patients with OI showed higher rates of ECG abnormalities and cardiac symptoms compared to controls.
  • OI patients exhibited significantly lower RV and LV systolic peak velocities and altered diastolic function parameters.
  • Multivariate analysis identified OI as an independent risk factor for RV systolic and diastolic dysfunction.

Conclusions:

  • Cardiac symptoms and ECG changes are frequent in individuals with Osteogenesis imperfecta.
  • The study suggests impaired RV and LV systolic and diastolic function in OI patients.
  • OI was confirmed as an independent predictor of reduced RV systolic and diastolic function.
Abstract

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