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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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Fast single photon avalanche photodiode-based time-resolved diffuse optical tomography scanner.

Ying Mu1, Mark Niedre2

  • 1Department of Electrical and Computer Engineering, Dana Research Center, Northeastern University, Boston, MA, 02115, USA ; mu.y@husky.neu.edu.

Biomedical Optics Express
|September 30, 2015
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Summary
This summary is machine-generated.

This study introduces a new time-resolved diffuse optical tomography (DOT) scanner using fast single-photon avalanche photodiodes (SPADs). The improved instrument enhances image resolution by effectively reducing light scatter in biological tissues.

Keywords:
(170.3890) Medical optics instrumentation(170.6920) Time-resolved imaging(170.6960) Tomography

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Area of Science:

  • Biomedical optics
  • Medical imaging technology
  • Photonics and instrumentation

Background:

  • Diffuse optical tomography (DOT) resolution is limited by significant light scatter in biological tissues.
  • Early time-point photon scatter reduction in time-resolved DOT is crucial and depends on instrument temporal response.
  • Developing faster instruments is key to overcoming DOT resolution challenges.

Purpose of the Study:

  • To design and validate a novel single-photon avalanche photodiode (SPAD) based time-resolved DOT scanner.
  • To assess the instrument's capability in reconstructing inclusions within optical phantoms.
  • To demonstrate the utility of fast SPAD detectors for improving DOT imaging.

Main Methods:

  • Development of a time-resolved DOT scanner utilizing an array of fast SPADs, a femtosecond Titanium Sapphire laser, and single photon counting electronics.
  • Characterization of the instrument's temporal impulse response function width (59 ps).
  • Validation using symmetrical and irregularly shaped optical phantoms simulating small animal sizes.

Main Results:

  • Accurate reconstruction of the size and position of up to 4 absorbing inclusions in phantoms.
  • Observed improvement in image quality with earlier time windows, attributed to the instrument's rapid response.
  • Demonstrated feasibility of reconstructing small inclusions with high fidelity.

Conclusions:

  • Fast SPAD detectors significantly enhance the performance of time-resolved DOT.
  • The developed SPAD-based DOT scanner shows potential for improved resolution in biomedical imaging.
  • This technology offers a promising avenue for advancing in-vivo optical tomography.