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Implantation of the Syncardia Total Artificial Heart
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Renal Function Recovery with Total Artificial Heart Support.

Mohammed A Quader1, Adam M Goodreau, Keyur B Shah

  • 1From the *Department of Surgery, Division of Cardiothoracic Surgery, and †Department of Medicine, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 30, 2015
PubMed
Summary
This summary is machine-generated.

Total artificial heart (TAH) support improved renal function in 75% of patients with pre-existing renal insufficiency (RI). This included patients requiring dialysis, showing TAH can aid kidney function recovery.

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Area of Science:

  • Cardiology
  • Nephrology
  • Medical Devices

Background:

  • Heart failure patients often have co-existing renal insufficiency (RI).
  • Total artificial heart (TAH) is used for end-stage heart failure.
  • The impact of TAH on renal function recovery in RI patients is not fully understood.

Purpose of the Study:

  • To quantify renal function recovery in patients with RI supported by TAH.
  • To analyze renal function at 30, 90, and 180 days post-TAH implantation.

Main Methods:

  • Retrospective analysis of renal function data from TAH recipients (2008-2013).
  • RI defined as requiring hemodialysis or eGFR < 60 ml/min/1.73 m².
  • Evaluated estimated glomerular filtration rate (eGFR) changes over time.

Main Results:

  • 43.5% of TAH recipients had pre-existing RI (mean eGFR 48 ± 7 ml/min/1.73 m²).
  • 75% of patients with RI showed improved renal function post-TAH.
  • Significant improvement in eGFR noted at 90 days (p=0.05); trends observed at 30 and 180 days.

Conclusions:

  • Total artificial heart support can lead to renal function improvement in patients with significant pre-existing RI.
  • TAH may facilitate renal recovery even in patients requiring preoperative dialysis.
  • Further research is warranted to understand the mechanisms of renal recovery with TAH.