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Related Concept Videos

Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

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Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
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Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
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Engineered Vascularized Muscle Flap
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Transposition Flaps: Principles and Locations.

Brett P Blake1, Cassandra J Simonetta, Ian A Maher

  • 1*Department of Dermatology, Virginia Commonwealth University, Richmond, Virginia; †Department of Dermatology, Saint Louis University, St. Louis, Missouri.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|September 30, 2015
PubMed
Summary
This summary is machine-generated.

Transposition flaps are versatile tools for head and neck reconstruction after Mohs surgery. Proper technique ensures optimal cosmetic outcomes for defect repair.

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Area of Science:

  • Plastic Surgery
  • Dermatology
  • Head and Neck Surgery

Background:

  • Transposition flaps are commonly utilized for head and neck defect repair following tumor removal via Mohs micrographic surgery.
  • These flaps offer a reconstructive solution for defects resulting from oncologic surgery.

Purpose of the Study:

  • To review the fundamental principles of single-stage transposition flaps.
  • To evaluate the application and effectiveness of transposition flaps based on their location on the head and neck.

Main Methods:

  • A comprehensive literature review was conducted on transposition flap techniques.
  • The review focused on principles, variations (e.g., rhomboid, multilobed flaps), and common anatomical sites for transposition flap use.

Main Results:

  • Transposition flaps require less undermining compared to large sliding flaps.
  • They excel at redirecting tension away from surgical defects and free margins.
  • Optimal cosmetic results depend on precise flap sizing, adequate undermining, and meticulous closure.

Conclusions:

  • The adaptability of transposition flaps makes them ideal for head and neck defect reconstruction.
  • Adherence to key principles and techniques facilitates achieving aesthetically pleasing results.