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Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences
Roya Tavallaie1, Nadim Darwish2, D Brynn Hibbert2
1School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia. Justin.gooding@unsw.edu.au and Australian Centre for NanoMedicine, The University of New South Wales, Sydney, NSW 2052, Australia.
Abstract:
The influence of RNA versus DNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These data are of particular importance for microRNA biosensors.
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