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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

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Updated: Apr 1, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Current developments in cell- and biomaterial-based approaches for stroke repair.

Pavla Jendelová¹, Šárka Kubinová², Ioanna Sandvig³

¹a 1 Institute of Experimental Medicine ASCR, Department of Neuroscience , Prague, Czech Republic +420 2 41 06 22 82 ; +420 2 41 06 27 06 ; jendel@biomed.cas.cz.

Expert Opinion on Biological Therapy

|October 1, 2015

Summary

New stroke therapies focus on cell transplantation. Neural precursors show promise over mesenchymal stem cells for CNS repair, offering a path for clinical translation.

Keywords:

clinical trials ischemic lesion mesenchymal stem cells neural progenitors neurogenesis noninvasive imaging stem cells stroke translation

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Published on: January 10, 2018

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Last Updated: Apr 1, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells

Published on: April 13, 2018

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Area of Science:

Neuroscience
Regenerative Medicine
Biomaterials Science

Background:

Stroke is a leading cause of death and disability globally.
Current treatments like clot retrieval and thrombolysis require early intervention.
Emerging strategies aim to promote repair through angiogenesis, neurogenesis, and immunomodulation.

Purpose of the Study:

To review stem cell types and biomaterials for stroke therapy.
To discuss administration routes and imaging techniques.
To identify prerequisites and challenges for clinical translation of cell therapies.

Main Methods:

Review of various stem cell types: neural progenitors, pluripotent stem cell derivatives, mesenchymal stem cells (MSCs), and olfactory ensheathing cells.
Analysis of biomaterials and administration routes for cell delivery.
Examination of noninvasive imaging methods for tracking cell therapies.
Identification of hurdles in translating cell therapies to clinical practice.

Main Results:

Neural precursors (NPs) derived from pluripotent stem cells offer advantages over MSCs.
NPs can remodel the central nervous system (CNS) by enhancing neuroplasticity, angiogenesis, and immunomodulation.
NPs have the potential to replace damaged cells in the CNS.

Conclusions:

Neural precursors demonstrate significant potential for CNS repair post-stroke.
Guidelines for researchers are proposed to facilitate the clinical transfer of NP therapies.
Successful clinical translation requires addressing specific prerequisites and overcoming identified hurdles.