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Circulating Levels of Uric Acid and Risk for Metabolic Syndrome
Alberto F Rubio-Guerra1, Herlinda Morales-López, Ana K Garro-Almendaro
1Hospital General de Ticoman SS DF. Mexican Group for Basic and Clinical Research in Internal Medicine, Motozintla, Mexico.
Insights
Young adults with hyperuricemia (high uric acid) have a significantly higher probability of developing metabolic syndrome. This association was particularly strong in men and linked to increased waist circumference.
Area of Science:
- Endocrinology
- Metabolic Health
- Public Health
Background:
- Hyperuricemia is linked to insulin resistance, which impairs uric acid excretion, creating a cycle that elevates serum uric acid and contributes to metabolic syndrome.
- Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
Purpose of the Study:
- To investigate the likelihood of developing metabolic syndrome in young, low-income adults experiencing hyperuricemia.
Main Methods:
- 103 low-income patients under 40 without cardiovascular disease history were assessed for metabolic syndrome using International Diabetes Federation criteria.
- Hyperuricemia was defined as serum uric acid levels ≥6.5 mg/dl for men and ≥5.1 mg/dl for women.
- Statistical analysis utilized odds ratios to determine the association between hyperuricemia and metabolic syndrome.
Main Results:
- A significant 5.1-fold increased odds of metabolic syndrome was observed in patients with hyperuricemia (p=0.002).
- Stronger associations were found in men (odds ratio 10.2, p=0.015) compared to women (odds ratio 3.6, p=0.048).
- Hyperuricemia showed a positive correlation only with increased waist circumference (r=0.483).
Conclusions:
- Hyperuricemia is significantly associated with metabolic syndrome in young, low-income Mexican adults.
- The findings highlight the importance of monitoring uric acid levels in this demographic for early metabolic syndrome detection.
Abstract:
Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome. The aim of this study is to evaluate the probability for the development of metabolic syndrome in low-income young adults with hyperuricaemia.
Methods:
We evaluated 103 patients less than 40 years of age, from a low-income population, and without history of cardiovascular disease, in all of them the presence of metabolic syndrome was assessed in accordance with the International Diabetes Federation criteria. In all patients, fasting serum uric acid levels were measured; hyperuricaemia was defined as serum uric acid values 6.5 mg/dl in men and 5.1 mg/dl in women. Statistical analysis was performed with odds ratio.
Results:
83 of our patients (80.5%) suffered metabolic syndrome, the odds ratio for the presence of metabolic syndrome in patients with hyperuricaemia was 5.1 (p=0.002, I.C 1.8- 14.5). When patients were evaluated by gender a significantly association between hyperuricaemia and metabolic syndrome was found in women (odds ratio 3.6, p=0.048, C.I. 1.0-12.9), and men (odds ratio 10.2, p= 0.015, IC 1.5-13.2). When uric acid was correlated with the components of metabolic syndrome, we only found a positive correlation with waist circumference (r=0.483).
Conclusion:
Our results showed a significant association between hyperuricemia and metabolic syndrome in low-income young adults in Mexico. DR is associated with estimated risk of CVD in type 2 diabetic patients.
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