Related Experiment Videos
Stereocontrolled synthesis of peptide bond isosteres
1Department of Chemistry, University of Texas, Austin 78712.
Chirality
|January 1, 1989
Abstract:
Absolute stereochemical control is employed in the synthesis of isosteres for dipeptide subunits (1; see Fig. 1) in which the amide linkage has been replaced by a trans carbon-carbon double bond. The synthesis affords access to the four stereoisomers of 1 in which R and R' = CH3, including the isostere for D-alanine-D-alanine (D-Ala-D-Ala), 2.