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Updated: Aug 26, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Recent Advances in Enantioselective Desymmetrization Enabled by Chiral Phosphoric Acid Catalysis
Dekun Zhang1, Bubin Xu1, Yuxiu Yang1
1School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi Province, China.
Abstract:
Enantioselective desymmetrization represents an efficient strategy for accessing enantioenriched products from relatively simple achiral starting materials, and it has been widely recognized as a pivotal approach in asymmetric synthesis. As one of the most versatile organocatalysts identified to date, chiral phosphoric acids (CPAs) have been extensively applied in the aforementioned research field. In this review, we summarized the substantial advances in enantioselective desymmetrization reactions enabled by CPA catalysis. Additionally, representative cases involving CPAs as cooperative catalysts are also discussed in detail.
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