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Updated: Aug 10, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Treatment of Acute Ischemic Stroke with Intravenous Urokinase (TASK-UK): Protocol for a Multicenter, Prospective,
Yongli Tao1, Hui Fang1, Lulu Pei1
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Background:
Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are both recommended for acute ischemic stroke (AIS) in China. Compared with rt-PA, UK is less expensive and more widely available in clinical practice.
Objective:
The Treatment of Acute Ischemic Stroke with Intravenous Urokinase (TASK-UK) study aims to investigate clinical outcomes among patients with AIS who receive UK thrombolysis, and to compare efficacy and cost-effectiveness between UK and rt-PA.
Methods:
TASK-UK is a multicenter, real-world observational study, with a planned sample size of 1000 patients in the UK group and 800 in the rt-PA group. This study enrolls patients with AIS who are eligible for intravenous thrombolysis from 20 participating centers and conducts follow-up until 90 days after thrombolysis.
Planned Outcomes:
The primary efficacy outcome is functional independence at 90 days, defined as a modified Rankin scale (mRS) score of 0-2. The primary safety outcome is symptomatic intracranial hemorrhage (sICH) occurring within 22-36 h after thrombolysis. The exploratory outcome is defined as an intergroup comparison of direct medical costs during hospitalization.
Discussion:
The TASK-UK study will provide high-quality real-world evidence on the effectiveness and cost-effectiveness of UK thrombolysis for AIS.
Trial Registry Number:
NCT06194968 (ClinicalTrials.gov).
