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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Updated: Apr 1, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
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Imaging Immunosenescence.

Feng Qian1,2, Ruth R Montgomery3

  • 1Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street/TAC S413, New Haven, CT, 06520, USA.

Methods in Molecular Biology (Clifton, N.J.)
|October 1, 2015
PubMed
Summary
This summary is machine-generated.

Aging research requires robust methods to detect subtle efficiency changes. Amnis ImageStream technology offers quantitative, reproducible imaging to examine cellular mechanisms in aging studies, even with limited samples.

Keywords:
AgingDendritic cellFlow cytometryImage analysisImmune responseMicroscopyMonocyteNeutrophilSignal transduction

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Area of Science:

  • Gerontology
  • Cellular Biology
  • Biotechnology

Background:

  • Demonstrating aging effects visually necessitates reliable techniques.
  • Detecting minor differences in efficiency or kinetics between groups is crucial for aging research.

Purpose of the Study:

  • To highlight the benefits of Amnis ImageStream technology for aging research.
  • To showcase a robust technique for visualizing and quantifying aging-related cellular changes.

Main Methods:

  • Utilizing Amnis ImageStream technology.
  • Combining quantitative flow cytometry with high-resolution digital imaging.
  • Analyzing cellular mechanisms and kinetics in aging cohorts.

Main Results:

  • ImageStream technology provides quantitative and reproducible data.
  • The technique is feasible even with limited sample sizes.
  • Facilitates in-depth examination of cellular mechanisms.

Conclusions:

  • Amnis ImageStream technology is a valuable tool for aging research.
  • It enables precise detection of subtle differences in cellular function.
  • Supports comprehensive cellular analysis in aging studies.