The Relationship Between Some Complete Blood Count Parameters and Myocardial Perfusion: A Scintigraphic Approach

Area of Science:

• Cardiology
• Hematology
• Biochemistry

Background:

• Complete blood count (CBC) markers like neutrophil/lymphocyte (N/L) ratio, platelet/lymphocyte (P/L) ratio, platelet distribution width (PDW), and red blood cell distribution width (RDW) have been associated with coronary artery disease (CAD).
• Understanding the relationship between these CBC-derived inflammatory and biochemical markers and myocardial perfusion is crucial for diagnosing and managing CAD.

Purpose of the Study:

• To investigate the association between N/L ratio, P/L ratio, PDW, and RDW values with myocardial perfusion in patients diagnosed with CAD.
• To determine if these CBC markers correlate with myocardial perfusion abnormalities assessed by myocardial perfusion scintigraphy (MPS).

Main Methods:

• A study involving 262 patients (149 with myocardial ischemia/infarction, 113 with normal perfusion) who underwent MPS.
• CBC was performed within 90 days of MPS.
• Myocardial perfusion parameters (e.g., summed stress score, summed difference score) were compared with N/L ratio, P/L ratio, PDW, and RDW values.

Main Results:

• Neutrophil counts and N/L ratios were significantly elevated in patients with myocardial ischemia and/or infarction.
• No statistically significant relationship was found between myocardial perfusion abnormalities and P/L ratio, PDW, or RDW values.
• The N/L ratio demonstrated a correlation with myocardial ischemia/infarction and left ventricular ejection fraction (LVEF).

Conclusions:

• The N/L ratio is a potential indicator associated with myocardial ischemia/infarction in CAD patients.
• While P/L ratio, PDW, and RDW did not show significant associations with perfusion abnormalities, the N/L ratio warrants further investigation in CAD management.