[Hallucinogen Persisting Perception Disorder (HPPD) and Flashback Phenomena – Differential Diagnosis and Explanation...

Area of Science:

• Neuroscience
• Psychiatry

Context:

• Hallucinogen Persisting Perception Disorder (HPPD) and flashback phenomena have unclear definitions and diagnostic features.
• These conditions have been used interchangeably since the 1960s.

Purpose:

• To provide an overview of current research on HPPD and flashbacks.
• Clarify the definitions and diagnostic features of these hallucinogen-related disorders.

Summary:

• Flashbacks are brief perceptual and mood alterations reminiscent of hallucinogen intoxication, often considered benign.
• HPPD is a DSM-5 visual perceptual disorder causing significant distress, with unknown prevalence and elusive pathophysiological mechanisms.
• Despite numerous etiological and therapeutic approaches, HPPD remains a puzzling disorder.

Impact:

• Highlights the need for further research into the pathophysiology of HPPD.
• Discusses clinical consequences and emerging therapeutic strategies for HPPD.
• Emphasizes the distinction between transient flashbacks and persistent HPPD.