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Choroid plexus papilloma in early infants
H Kawano1, M Hayashi, H Kobayashi
1Department of Neurosurgery, Fukui Medical School, Japan.
Insights
Successful surgical treatment for choroid plexus papillomas in infants is highlighted. Early diagnosis and intervention are crucial for managing increased intracranial pressure and hydrocephalus, leading to positive developmental outcomes.
Area of Science:
- Pediatric Neurosurgery
- Neuro-oncology
- Developmental Pediatrics
Background:
- Choroid plexus papillomas are rare tumors often presenting in infancy.
- These tumors can lead to hydrocephalus due to cerebrospinal fluid (CSF) overproduction or obstruction.
Observation:
- Four infants presented with symptoms of increased intracranial pressure and hydrocephalus within 8 weeks of birth.
- Tumors were located in the lateral ventricles, with three being benign and one malignant choroid plexus papilloma.
- Computerized tomography (CT) scans were instrumental in diagnosing both the tumors and associated hydrocephalus.
Findings:
- Surgical resection was the primary treatment, achieving successful outcomes in all four cases.
- Angiography revealed tumor staining in two patients, aiding in surgical planning.
- Three infants demonstrated normal physical and mental development post-surgery.
Implications:
- Early diagnosis and surgical management of choroid plexus papillomas are vital for preventing severe neurological deficits.
- Prompt treatment of hydrocephalus associated with these tumors is critical for favorable neurodevelopmental trajectories.
- This case series underscores the efficacy of surgical intervention in pediatric choroid plexus papilloma management.
Abstract:
Four infants with choroid plexus papillomas which were successfully treated with surgery are described. All patients showed the clinical signs of increased intracranial pressure and hydrocephalus within 8 weeks after birth. The tumors were in the lateral ventricles and histologically three of them were benign papillomas and other one was a malignant papilloma. Computerized tomography scan was useful for the diagnosis of both of the tumor and the hydrocephalus that was caused by the overproduction of cerebrospinal fluid and/or the obstruction of it's pathway. The tumor stain on the angiograms was noticed in two patients. Three patients have grown normally in both physical and mental functions after the surgical treatment, whereas one showed psychomotor retardation because of poorly controlled hydrocephalus.