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The Diarylprolinol Silyl Ethers: Ten Years After
Bjarke S Donslund1, Tore Kiilerich Johansen1, Pernille H Poulsen1
1Department of Chemistry, Aarhus University, 8000 Aarhus C (Denmark).
Diarylprolinol silyl ethers are powerful catalysts in asymmetric organocatalysis. This review highlights their activation modes and reaction concepts developed over ten years, showcasing their impact on modern synthetic chemistry.
Area of Science:
- Organic Chemistry
- Catalysis
Background:
- Asymmetric organocatalysis has rapidly advanced since 2000.
- Diarylprolinol silyl ethers, introduced in 2005, are key catalysts in aminocatalysis.
Purpose of the Study:
- To review the development and applications of diarylprolinol silyl ethers.
- To analyze the activation modes and reaction concepts associated with these catalysts.
Main Methods:
- Literature review focusing on diarylprolinol silyl ether catalysis.
- Analysis of reactivity patterns and combined activation strategies.
Main Results:
- Diarylprolinol silyl ethers are versatile and widely adopted catalysts.
- Diverse activation modes and reaction concepts have been developed.
Conclusions:
- Diarylprolinol silyl ethers have significantly impacted asymmetric synthesis.
- Continued exploration of their activation modes promises further advancements.
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