Renal calculi after shock wave lithotripsy: US evaluation with an in vitro phantom

Fragments of renal calculi from patients who had undergone extracorporeal shock wave lithotripsy (ESWL) were embedded in an in vitro tissue-equivalent ultrasound (US) phantom to assess (a) the accuracy with which such fragments could be measured; (b) the influence of stone composition, stone depth, and transducer frequency; and (c) the effect of fragment "clumping" on size determinations and acoustic shadowing. Fragments as small as 0.8 mm in diameter could be detected at 7.5 MHz, although a practical limitation of 1-2 mm for lower transducer frequencies (3.5 and 5.0 MHz) was observed. Fragment diameter tended to be overestimated with US by a mean of 1 mm. Transducers of 5 and 7.5 MHz were more accurate in determination of size than 3.5-MHz transducers. Struvite fragments were less echogenic and were therefore measured more accurately, but smaller struvite fragments were less detectable than other fragment types. Fragment "clumping" led to significant overestimation of residual stone size even when small fragments were separated by as much as the distance equal to the diameter of one fragment. This study demonstrates that even under the best circumstances the disadvantages of US in assessing residual stone disease are significant.