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Synthetic cannabinoids and acute kidney injury
Weeraporn Srisung1, Faisal Jamal1, Sharma Prabhakar1
1Department of Internal Medicine (Srisung, Jamal, Prabhakar) and the Division of Nephrology (Jamal, Prabhakar), Texas Tech University Health Sciences Center, Lubbock, Texas.
Proceedings (Baylor University. Medical Center)
|October 2, 2015
Summary
Synthetic cannabinoids (SCBs) are recreational drugs causing psychoactive effects. Recent cases show SCBs can lead to acute kidney injury (AKI), a serious adverse event with unknown causes.
Area of Science:
- Toxicology
- Nephrology
- Pharmacology
Background:
- Synthetic cannabinoids (SCBs) are increasingly used recreationally, particularly by young adults.
- SCBs are associated with various adverse health effects.
- The mechanism of SCB-induced acute kidney injury (AKI) remains unclear.
Observation:
- This study reports three cases of AKI in individuals who used SCBs.
- Patients presented with elevated serum creatinine levels, ranging from 3.0 to 5.7 mg/dL.
- One patient required hemodialysis due to the severity of kidney injury.
Findings:
- Synthetic cannabinoid use is linked to the development of acute kidney injury.
- SCB-induced AKI can be severe, necessitating intensive medical intervention.
- The pathophysiology underlying SCB-induced nephrotoxicity requires further investigation.
Implications:
- Clinicians should consider SCB use in patients presenting with unexplained AKI.
- Increased awareness and research are needed to understand and prevent SCB-related kidney damage.
- This finding highlights the potential public health risks associated with synthetic cannabinoid consumption.
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