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The Intestinal Microbiome in Bariatric Surgery Patients
Christine M Peat1, Susan C Kleiman2, Cynthia M Bulik1,2,3
1Department of Psychiatry, University of North Carolina at Chapel Hill, USA.
Summary
Bariatric surgery impacts gut microbiota, influencing weight loss and fat storage. This review explores how intestinal microbes affect physiological and psychological traits in patients undergoing obesity surgery.
Area of Science:
- Obesity and Public Health
- Gastroenterology and Metabolism
- Microbiome Research
Background:
- Obesity affects 39% of adults globally, posing a significant public health challenge.
- Bariatric surgery is increasingly popular due to limited success of behavioral and pharmacological interventions.
- Initial theories focused on mechanical effects, but indirect factors like the gut microbiota are now recognized.
Purpose of the Study:
- To review the influence of the intestinal microbiota on physiological and psychological traits of bariatric surgery candidates.
- To examine how bariatric surgery impacts the gut microbiota composition and function.
- To synthesize current evidence on the role of the gut microbiome in surgery-mediated weight loss and maintenance.
Main Methods:
- Literature review of studies investigating bariatric surgery and the intestinal microbiota.
- Analysis of human and mouse model studies.
- Discussion of physiological and psychological factors influenced by the gut microbiome.
Main Results:
- Evidence suggests the intestinal microbiota plays a crucial role in surgery-mediated weight loss.
- Bariatric surgery significantly alters the gut microbial community structure and function.
- Microbiota-influenced factors contribute to the accumulation and storage of fat post-surgery.
Conclusions:
- The gut microbiota is a key factor in the efficacy of bariatric surgery for obesity treatment.
- Understanding microbiota-host interactions is vital for optimizing weight loss and long-term maintenance.
- Further research into microbiota modulation could enhance bariatric surgery outcomes.
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