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Tremelimumab-associated tumor regression following after initial progression: two case reports
Akihiko Shimomura1,2, Yutaka Fujiwara1, Shunsuke Kondo1
1Department of Experimental Therapeutics, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Immunotherapy
|October 3, 2015
Summary
Tremelimumab, an immune checkpoint inhibitor, showed delayed tumor shrinkage in bile duct and unknown primary cancers after initial progression. This suggests potential for treating solid tumors with tremelimumab therapy.
Area of Science:
- Immunotherapy
- Oncology
- Clinical Case Studies
Background:
- Tremelimumab is a human IgG2 monoclonal antibody targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4).
- Anti-CTLA-4 therapies can exhibit unique kinetics, with delayed antitumor responses following initial disease progression.
Observation:
- Two cases are presented: one with bile duct cancer and another with squamous cell carcinoma of unknown primary.
- Both patients experienced rapid initial disease progression after tremelimumab treatment.
Findings:
- Dramatic tumor shrinkage was observed in both cases after one or two doses of tremelimumab.
- No immune-related adverse events were reported in these patients.
Implications:
- The delayed yet significant antitumor response suggests tremelimumab's potential efficacy in solid tumors.
- These findings warrant further investigation into tremelimumab's role in cancer immunotherapy.
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