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Exercise genomics--a paradigm shift is needed: a commentary.

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    Summary
    This summary is machine-generated.

    Exercise genomics research needs a paradigm shift, focusing more on mechanistic studies and unbiased genome exploration. Large-scale, collaborative efforts are crucial for understanding exercise biology, behavior, and sports performance.

    Keywords:
    Exercise

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    Area of Science:

    • Exercise genomics
    • Human biology
    • Sports science

    Background:

    • Exercise genomics aims to understand exercise biology, behavior, and the impact of genetic variation on physical attributes and sports performance.
    • Current research often focuses on common variants, limiting a comprehensive understanding.

    Purpose of the Study:

    • To review the current status of exercise genetics and genomics.
    • To propose improvements for the research agenda and translational activities in exercise genomics.

    Main Methods:

    • Defining genomic features relevant to exercise biology.
    • Highlighting limitations of focusing on common variants.
    • Discussing the need for a paradigm shift towards mechanistic and functional research.
    • Emphasizing appropriately powered and experimental study designs, including Mendelian randomization.
    • Advocating for unbiased genome exploration using genomics, epigenomics, and transcriptomics.
    • Stressing the importance of replication and large-scale, collaborative research programs.

    Main Results:

    • Current exercise genomics research has limitations due to a narrow focus on common variants.
    • A significant shift towards experimental, mechanistic investigations is needed.
    • Unbiased exploration of the genome combined with robust study designs is essential.

    Conclusions:

    • Exercise genomics requires a major paradigm shift in research design and focus.
    • Increased emphasis on mechanistic studies, unbiased genome exploration, and large-scale collaboration is recommended.
    • Translational activities must align with best practices to maximize the benefits of exercise genomics.