Related Experiment Video
Updated: Apr 1, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
The Outcome of Severe Internalizing and Disruptive Disorders from Preschool into Adolescence:A Follow-up Study
Sara Spitzer1, Ornit Freudenstein1, Miriam Peskin2
1Division of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tikva, Israel.
Insights
Children
Area of Science:
- Child and Adolescent Psychiatry
- Developmental Psychology
- Pediatric Mental Health
Background:
- Severe psychiatric disorders in preschool children can have long-term impacts.
- Understanding developmental trajectories is crucial for early intervention.
- Limited research exists on the long-term outcomes of preschool psychiatric disorders.
Purpose of the Study:
- To investigate the long-term outcomes of severe psychiatric disorders in preschool children.
- To examine the developmental trajectories from early childhood through adolescence.
- To identify factors influencing recovery rates based on initial diagnosis.
Main Methods:
- A cohort of 40 preschool children with severe psychiatric disorders was evaluated.
- Participants were assessed at a tertiary referral mental health center.
- Follow-up evaluations were conducted 5.5 years after initial assessment.
Main Results:
- Children with internalizing disorders at baseline showed a 58.3% recovery rate (p=0.02).
- Children with disruptive disorders at baseline had a 43.7% recovery rate (p=0.02).
- Only 8.3% of children with comorbid disruptive-internalizing disorders at baseline achieved full remission (p=1.0).
Conclusions:
- Preschool psychiatric disorder trajectories resemble community samples but vary by diagnosis.
- Internalizing disorders have a significantly better recovery rate than comorbid disruptive-internalizing disorders.
- Early diagnosis and targeted interventions are critical for improving long-term outcomes.
Purpose:
In this study we aimed to examine the outcome of children's severe psychiatric disorders from preschool into later childhood and adolescence.
Method:
Forty preschool children (28 boys and 12 girls) treated in a tertiary referral mental health center, evaluated at admission and 5.5 ± 1.2 years thereafter.
Results:
Seven (58.3%) children diagnosed with internalizing disorders at baseline were free of any psychiatric diagnosis at follow-up (p=0.02). Conversely, only one child (8.3%) diagnosed with comorbid disruptive-internalizing disorders at baseline was free of any psychiatric disorder at follow-up (p=1.0). Seven (43.7%) children diagnosed with disruptive disorders at baseline were free of psychiatric diagnoses at follow-up (p=0.02).
Limitations:
The small sample size and naturalistic nature of the study.
Conclusion:
The trajectories of severe psychiatric disorders at preschool years are similar to those reported in community samples and differ according to the baseline diagnosis. Children with internalizing disorders show a much better recovery rate than those with comorbid disruptive and internalizing disorders.
More Related Videos
07:15Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
Published on: March 15, 2024
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
Related Concept Videos
Conduct Disorder
Oppositional Defiant Disorder
Diagnostic Criteria and...
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Social Foundations of Self II: The Generalized Other
Bullying
Self-Evaluation: Self-Enhancement and Self-Verification