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Updated: Apr 1, 2026

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
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Microglia Plasticity During Health and Disease: An Immunological Perspective

Anat Shemer1, Daniel Erny2, Steffen Jung1

  • 1Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

Trends in Immunology
|October 4, 2015
PubMed

Insights

Microglia, the central nervous system's immune cells, adapt their function throughout life. Understanding microglia responsiveness is key to manipulating them for disease reduction.

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Microglia are macrophages of the central nervous system (CNS).
  • They play crucial roles in embryonic development and neuronal network formation.
  • Microglia undergo significant phenotype and functional changes from development to adulthood.

Purpose of the Study:

  • To discuss myeloid cell biology with a focus on microglia.
  • To highlight the shifting roles of microglia in CNS integrity.
  • To explore microglia responsiveness to diverse stimuli for potential therapeutic applications.

Main Methods:

  • Review of current literature on microglia and myeloid cell biology.
  • Emphasis on developmental and adult microglial functions.
  • Discussion of immune-mediated mechanisms in the CNS.

Main Results:

  • Microglia are essential for shaping the developing nervous system.
  • Adult microglia contribute to both homeostasis and inflammatory processes.
  • Microglia possess a remarkable ability to adjust to environmental cues.

Conclusions:

  • Understanding microglia's dynamic nature is vital for CNS health.
  • Targeting microglia responsiveness could offer new therapeutic strategies for neurological diseases.
  • Further research into microglia biology is crucial for advancing CNS disease management.

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