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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney

Mehmet Baha Aytaç1, Murat Deveci2, Kenan Bek3

  • 1Department of Pediatric Nephrology, Kocaeli University, Medical Faculty, Izmit, Turkey. mbaha_79@hotmail.com.

Pediatric Nephrology (Berlin, Germany)
|October 4, 2015
PubMed

Insights

Vitamin D supplementation improved cardiac and endothelial function in children with chronic kidney disease (CKD). This study highlights the importance of vitamin D for cardiovascular health in pediatric CKD patients.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health
  • Endocrinology

Background:

  • Cardiovascular disease is a primary cause of mortality in children with chronic kidney disease (CKD).
  • Vitamin D deficiency is common in pediatric CKD patients, potentially exacerbating cardiovascular risks.

Purpose of the Study:

  • To investigate the impact of oral cholecalciferol (vitamin D3) supplementation on cardiac parameters.
  • To assess changes in biomarkers of endothelial cell activation in children with CKD following vitamin D treatment.

Main Methods:

  • Echocardiography and vascular stiffness measurements were performed basally and post-supplementation in 41 children with CKD and 24 healthy controls.
  • Evaluated markers included flow-mediated dilatation (FMD), arterial stiffness, homocysteine, and von Willebrand factor.

Main Results:

  • Children with CKD exhibited lower FMD and higher arterial stiffness compared to controls.
  • Vitamin D supplementation significantly improved FMD and reduced arterial stiffness in the CKD group.
  • Homocysteine levels correlated inversely with baseline vitamin D, and von Willebrand factor was an independent risk factor for FMD impairment.

Conclusions:

  • High-dose cholecalciferol positively impacts cardiovascular and endothelial function in children with CKD.
  • Vitamin D supplementation is crucial for managing cardiovascular risk in pediatric CKD.
Abstract

Keywords:
25-hydroxyvitamin D3Arterial stiffnessChildrenChronic kidney diseaseFlow-mediated dilatation

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