Ambulatory (Holter) electrocardiography and myocardial ischemia

Ambulatory (Holter) electrocardiography has evolved over the past two decades to allow accurate assessment of the cardiac rhythm, and more recently, accurate detection and measurement of ST segment changes. These ambulatory ECG ST segment changes that occur with and without symptoms, although thought to be of questionable clinical value for many years, have recently been clearly documented in coronary artery disease patients to represent true myocardial ischemia. Concurrent with these technologic developments has been an evolution of the pathophysiologic understanding of myocardial ischemia, and the relative role and sequential nature that ECG ST segment changes have in its development. This review examines from a clinical perspective the current understanding of the pathophysiologic sequence of development of myocardial ischemia, emphasizes the ECG diagnostic methods that detect this sequential change, examines the criteria that define ambulatory ECG myocardial ischemia, and discusses those nonischemic factors that affect the ECG ST segment and its interpretation. Moreover, an ever increasing number of ambulatory ECG studies of coronary artery disease and normal patients have defined unique characteristics of the ambulatory ECG ST segment changes observed with regard to its diagnostic, prognostic, and therapeutic assessment value in the study of myocardial ischemia.