Related Experiment Video
Updated: Apr 1, 2026
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
Published on: October 20, 2010
Fluorescein sodium-guided surgery in cerebral lymphoma
Karl-Michael Schebesch1, Julius Hoehne1, Christoph Hohenberger1
1Department of Neurosurgery, Regensburg University Hospital, Germany; Wilhelm-Sander Neuro-Oncology Unit, Regensburg University Hospital, Germany.
Objectives:
Growth and progress of primary central nervous lymphoma (PCNSL) severely disrupt the blood brain barrier (BBB). Such disruptions can be intraoperatively visualized by injecting fluorescein sodium (FL) and applying a YELLOW 560 nm surgical microscope filter. Here, we report a small cohort of patients with PCNSL that mimicked high grade gliomas (HGG) or cerebral metastases (CM), who had been operated on with the use of FL.
Patients And Methods:
Retrospectively, seven patients with PCNSL were identified, who had been operated on by means of microsurgery after intravenous FL injection. The surgical reports were screened for statements on the grade of fluorescent staining in the tumor area. One representative case was chosen to show the staining under white light as well as under filtered light at different distances to the tumor area.
Results:
All patients had shown bright and homogenous fluorescent staining of the tumor (n=7. 100%). No adverse effects had been observed.
Conclusion:
Similar to patients with HGG or CM, patients with PCNSL may benefit from use of FL and the dedicated YELLOW 560 nm filter in open surgery.
More Related Videos
06:59Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
03:23Fluorescent Laparoscopic Central Hepatectomy for Liver Cancer Using Indocyanine Green Negative Staining
Published on: March 17, 2023