Related Experiment Video

Updated: Apr 1, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

14.7K

PDCD5 functions as a regulator of p53 dynamics in the DNA damage response

Changjing Zhuge1, Xiaojuan Sun2, Yingyu Chen3

  • 1College of Sciences, Beijing Forestry University, 35 Tsinghua East Road, Beijing 100083, China.

Journal of Theoretical Biology
|October 4, 2015
PubMed

Insights

Programmed Cell Death 5 (PDCD5) acts as a co-activator for the tumor suppressor p53, influencing cell fate decisions after DNA damage. PDCD5 regulates p53 dynamics, impacting apoptosis and potentially enhancing cancer therapies.

Area of Science:

  • Molecular Biology
  • Computational Biology
  • Cancer Research

Background:

  • The tumor suppressor p53 is crucial for cellular responses to DNA damage.
  • Programmed Cell Death 5 (PDCD5) interacts with the p53 pathway to promote apoptosis.
  • PDCD5 has shown potential in sensitizing cancers to chemotherapy.

Purpose of the Study:

  • To construct a computational model of the p53 signaling network including PDCD5.
  • To investigate the effects of PDCD5 on p53-mediated cell fate decisions.
  • To understand the regulatory role of PDCD5 in the DNA damage response.

Main Methods:

  • Development of a computational model incorporating PDCD5 into the p53 signaling network.
  • Simulation of p53 dynamics under varying PDCD5 levels following DNA damage.
  • Analysis of PDCD5's impact on caspase-3 activation.

Main Results:

  • PDCD5 acts as a co-activator of p53, modulating p53 dynamics.
  • PDCD5 influences cell fate decisions in a dose-dependent manner, leading to sustained low, pulsed, or sustained high p53 activity.
  • PDCD5 regulates caspase-3 activation through distinct mechanisms during different p53 dynamic phases.

Conclusions:

  • PDCD5 is a key regulator of the p53 pathway, influencing cell fate decisions.
  • Understanding PDCD5's role in p53 dynamics offers insights into cancer treatment strategies.
  • PDCD5's ability to modulate p53 activity and apoptosis suggests therapeutic potential in oncology.
Keywords:
ApoptosisDNA damageMathematical modelP53PDCD5

More Related Videos

Yeast As a Chassis for Developing Functional Assays to Study Human P5314:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

10.2K
Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications10:12

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

3.8K

Related Concept Videos

DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.4K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.4K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
39.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.2K
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
7.1K