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Related Experiment Video

Updated: Apr 1, 2026

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

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Published on: September 5, 2025

The Master Protocol Concept.

Mary W Redman¹, Carmen J Allegra²

¹Clinical Biostatistics, Clinical Research Division, Lead Statistician, SWOG Lung Committee and Lung-MAP trial; Fred Hutchinson Cancer Research Center, Seattle, WA.

Seminars in Oncology

|October 5, 2015

Summary

This summary is machine-generated.

Master Protocols enable efficient testing of targeted cancer therapies by leveraging rapid genomic sequencing. These innovative platforms streamline drug development for precision oncology in specific patient groups.

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Area of Science:

Biomedical Technology
Genomics
Oncology

Background:

Genomic sequencing costs and timelines have drastically decreased since 2003.
Next-generation sequencing facilitates the advancement of precision oncology.
Testing numerous targeted agents requires novel therapeutic platforms.

Purpose of the Study:

Introduce the Master Protocol concept for therapeutic development.
Discuss the advantages and challenges of Master Protocols.
Provide an overview of active and developing Master Protocols.

Main Methods:

Description of the Master Protocol design.
Focus on the Lung Master Protocol (Lung-MAP study).
Review of current Master Protocol initiatives.

Main Results:

Master Protocols are designed for efficient testing of targeted agents.
These platforms address the need for testing in small patient subpopulations.
The Lung-MAP study serves as a detailed example.

Conclusions:

Master Protocols represent a significant advancement in oncology drug development.
The design offers gains in efficiency and effectiveness for targeted therapies.
Further exploration of Master Protocols is warranted for precision medicine.