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Resistance to Immune Checkpoint Inhibitor Treatment in Non-Small Cell Lung Cancer Clinical Trials: A Perspective From

Deborah B Doroshow1, Ticiana A Leal2, Saiama N Waqar3

  • 1Icahn School of Medicine at Mount Sinai, New York, NY.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|June 3, 2026
PubMed
Abstract

No abstract available in PubMed .

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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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