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Monoclonal Antibodies

Larisa J Geskin1

  • 1Comprehensive Cutaneous Oncology Center, Department of Dermatology, Columbia University, 161 Fort Washington Avenue, 12th floor, New York, NY 10032, USA.

Dermatologic Clinics
|October 5, 2015
PubMed

Insights

Monoclonal antibodies (mAbs) have transformed cancer treatment, showing high efficacy and safety in cutaneous lymphomas. These targeted therapies offer promising sequential treatment options for patients.

Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Background:

  • Monoclonal antibodies (mAbs) represent a significant advancement in cancer therapy.
  • Targeted approaches against malignant cells and the tumor microenvironment are effective in hematologic malignancies, including cutaneous lymphomas.

Purpose of the Study:

  • To review the role and efficacy of mAb-based therapy in cutaneous T-cell lymphoma (CTCL).
  • To highlight the success of mAbs in clinical trials for CTCL, noting high response rates and a favorable toxicity profile.

Main Methods:

  • Review of clinical trial data and approved therapies involving monoclonal antibodies for CTCL.
  • Analysis of the therapeutic potential and safety profile of existing and emerging mAb treatments.

Main Results:

  • mAb-based therapy for CTCL has demonstrated high response rates in clinical trials.
  • These therapies exhibit a favorable toxicity profile, making them well-tolerated.
  • Several mAbs and antibody-based conjugates are approved, with numerous others in development.

Conclusions:

  • Monoclonal antibodies are a cornerstone of modern cancer therapy, particularly for CTCL.
  • Their efficacy, safety, and potential for sequential administration position them as valuable tools in managing cutaneous lymphomas.
Keywords:
Antibody conjugatesAntibody therapyClinical trialsCutaneous lymphoma

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