Relation Between Monocyte to High-Density Lipoprotein Cholesterol Ratio With Presence and Severity of Isolated

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Harun Kundi1, Murat Gok1, Emrullah Kiziltunc1

  • 1Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

The American Journal of Cardiology
|October 6, 2015
PubMed

Insights

The monocyte to HDL cholesterol ratio (MHR) is elevated in patients with coronary artery ectasia (CAE). Higher MHR correlates with increased CAE severity, suggesting its potential as an inflammatory marker.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation Research

Background:

  • Coronary artery ectasia (CAE) is a vascular condition requiring effective diagnostic markers.
  • Inflammatory and oxidative stress markers are implicated in cardiovascular diseases.
  • The monocyte to high-density lipoprotein cholesterol ratio (MHR) is an emerging biomarker.

Purpose of the Study:

  • To investigate the utility of the monocyte to high-density lipoprotein cholesterol ratio (MHR) as an inflammatory marker in patients with coronary artery ectasia (CAE).
  • To assess the relationship between MHR and the severity of isolated CAE.

Main Methods:

  • A study involving 405 patients: 135 with isolated CAE, 135 with obstructive coronary artery disease (CAD), and 135 with normal coronary angiograms (NCAs).
  • Measurement of MHR in all patient groups.
  • Severity of isolated CAE assessed using the Markis classification.
  • Linear regression analysis to determine associations between MHR, C-reactive protein, and CAE severity.

Main Results:

  • MHR was significantly higher in patients with isolated CAE (14.8) compared to those with obstructive CAD (11.4) and NCAs (9.8).
  • Linear regression revealed a significant association between MHR, C-reactive protein, and the severity of isolated CAE.

Conclusions:

  • The monocyte to high-density lipoprotein cholesterol ratio (MHR) is significantly elevated in patients with coronary artery ectasia (CAE).
  • MHR is associated with the severity of CAE, indicating its potential as a valuable inflammatory marker for this condition.

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