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Differences in Prognostic Factors between Early and Late Recurrence Breast Cancers
Mehrdad Payandeh1, Masoud Sadeghi, Edris Sadeghi
1Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran
Asian Pacific Journal of Cancer Prevention : APJCP
|October 6, 2015
Summary
Tumor size, p53, and lymph node metastasis are key predictors of breast cancer recurrence. P53 positivity is a significant factor for early recurrence within five years.
Area of Science:
- Oncology
- Cancer Research
- Clinical Medicine
Background:
- Breast cancer (BC) is a prevalent malignancy in women, contributing significantly to cancer-related mortality.
- Understanding baseline characteristics and recurrence patterns is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate baseline characteristics of breast cancer patients.
- To compare these characteristics between early and late recurrence groups.
Main Methods:
- Retrospective analysis of 86 female breast cancer patients with distant metastasis (1995-2014).
- Defined early recurrence (<5 years) and late recurrence (>5 years) post-surgery.
- Identified prognostic factors using Akaike Information Criterion.
Main Results:
- Median follow-up was 9 years; 51 recurrences (31 early, 20 late) observed.
- No recurrence group showed less lymph node involvement and more p53 positivity compared to early recurrence.
- Late recurrence group had smaller tumor size compared to early recurrence.
- p53 positivity was a significant prognostic factor for early recurrence (OR 6.94).
Conclusions:
- Tumor size, p53 status, and lymph node (LN) metastasis are critical for distant recurrence, particularly early recurrence.
- p53 positivity is a significant independent prognostic factor for early breast cancer recurrence.
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