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Hepatitis01:25

Hepatitis

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Related Experiment Video

Updated: Apr 1, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

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The hepatitis B virus receptor.

Wenhui Li1

  • 1National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing 102206, China;

Annual Review of Cell and Developmental Biology
|October 6, 2015
PubMed
Summary
This summary is machine-generated.

Sodium taurocholate cotransporting polypeptide (NTCP) acts as the cellular receptor for Hepatitis B virus (HBV) and Hepatitis D virus (HDV). This discovery is key for understanding viral entry and developing new HBV treatments.

Keywords:
NTCPbile acidshepatitis Bpathogenesistherapeuticstransporters

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Area of Science:

  • Hepatology
  • Virology
  • Molecular Biology

Background:

  • Hepatitis B virus (HBV) and Hepatitis D virus (HDV) infections impact millions globally.
  • The cellular receptor mediating HBV and HDV entry into hepatocytes remained elusive.
  • Sodium taurocholate cotransporting polypeptide (NTCP) is a liver-specific bile acid transporter.

Purpose of the Study:

  • To review the critical findings on NTCP's role as a viral receptor for HBV and HDV.
  • To discuss the implications of NTCP-mediated viral entry on liver tropism and host specificity.
  • To highlight unanswered questions in the field.

Main Methods:

  • Literature review of studies investigating NTCP's function in viral entry.
  • Analysis of data linking NTCP-mediated viral entry to bile acid and cholesterol metabolism.
  • Examination of cell culture models, including HepG2 cells complemented with NTCP.

Main Results:

  • NTCP is identified as the primary cellular receptor for HBV and HDV.
  • NTCP mediates viral entry, influencing liver tropism and species specificity.
  • NTCP-mediated entry affects bile acid transport and metabolism.

Conclusions:

  • NTCP is crucial for HBV and HDV infection at the cellular entry level.
  • Understanding NTCP's role offers new avenues for therapeutic interventions against HBV and HDV.
  • Further research is needed to fully elucidate the complex interactions between NTCP and these viruses.