Related Experiment Video
Updated: Apr 1, 2026

05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
858
[Cutaneous loxoscelism mainly edematous: a case report].
Summary
Cutaneous loxoscelism with edematous predominance (CLEP), a rare spider bite reaction, presents with significant swelling. This benign condition typically resolves with minimal necrosis and responds well to medical care.
Area of Science:
- Toxicology
- Dermatology
- Arachnology
Background:
- Loxoscelism in Chile results from Loxosceles laeta spider bites.
- Clinical manifestations include cutaneous loxoscelism (CL) and less common vicero-cutaneous loxoscelism.
- Cutaneous loxoscelism with edematous predominance (CLEP) is a rare variant (4%) of CL.
Observation:
- A 5-year-old patient presented with acute right eyelid pain and edema, progressing to involve the hemifacial area and other eyelids.
- Fever was associated with the initial symptoms.
- Differential diagnoses of angioedema and pre-orbital cellulitis were excluded, leading to suspicion of CLEP.
Findings:
- CLEP is characterized by significant edema, diluting the spider's venom.
- This dilution minimizes the enzymatic process responsible for necrosis.
- The condition is self-limited and generally benign, with little to no necrotic injury.
Implications:
- Early recognition of CLEP is crucial for appropriate management.
- Treatment is typically supportive and medical, leading to favorable outcomes.
- CLEP does not appear to involve visceral complications, distinguishing it from other forms of loxoscelism.
Related Concept Videos
Skin Cancer
6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
Skin Diseases and Disorders
6.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.2K
Reticular Dermis
5.5K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
5.5K
Staphylococcal Skin Infections
70
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
70
Papillary Dermis
6.8K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.8K
Acne Infection
50
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
50

